Pain is what I will attack you with,
A plague that appears once, what a myth.In your throat I'll sequester,
Now in your hands I'll fester.For if you see me lying around,
Unbelievable pain will take you down.Let's, not forget, if I touch you, you can't run away.
What am I?
Hint
You may get hot around me,
Your hands and feet will plea.
Hint 2:
A disease commonly found in children,
Sores will most always afflict them.
Edit: you are actually
Coxsackie Virus (hand foot and mouth)
Pain is what I will attack you with, A plague that appears once, what a myth.
A painful disease, especially for adults
In your throat I'll sequester, Now in your hands I'll fester.
Coxsackie starts its infection in the throat then moves to the skin
For if you see me lying around, Unbelievable pain will take you down.
This disease keeps you from walking when it spreads to your feet
Let's, not forget, if I touch you, you can't run away.
you can barely walk, nevermind run with this disease
Title: Don't confuse me with the one about chickens!
Not to be confused with chicken-pox
fun (not fun) bonus: I've had this. It's awful.
Original Answer:
Are you
Smallpox?
Pain is what I will attack you with, A plague that appears once, what a myth.
Smallpox is a painful disease which spreads like a plague
In your throat I'll sequester, Now in your hands I'll fester.
Smallpox starts its infection in the throat then moves to the skin
For if you see me lying around, Unbelievable pain will take you down.
Possibly a reference to 'smallpox blankets' in American history. Once touched, the painful disease was easily communicable
Let's, not forget, if I touch you, you can't run away.
Once you have the germs, you can not get away from the disease
Title: Don't confuse me with the one about chickens!
Not to be confused with chicken-pox, a much less serious disease
Are you a
Bruise
Pain is what I will attack you with, A plague that appears once, what a myth.
You get a bruise after you hit yourself on something, which causes pain.
In your throat I'll sequester, Now in your hands I'll fester.
I am not sure about this but you can get a bruise in you hand.
For if you see me lying around, Unbelievable pain will take you down.
Bruise's can hurt.
Let's, not forget, if I touch you, you can't run away.
Bruise's do not move until they get better.
Are you a
Pac-Man Ghost
Pain is what I will attack you with, A plague that appears once, what a myth.
255 levels of attacking, painful ghosts
In your throat I'll sequester,
The death animation suggests jaw-unhinging, possibly throat based damage
Now in your hands I'll fester.
Arcade joysticks are tough on the hands
For if you see me lying around, Unbelievable pain will take you down.
Get close enough to see the ghost and painful mouth expansion into nothingness ensues
Let's, not forget, if I touch you, you can't run away.
A touch by the ghost ends Pac-Man's fleeing
Maybe you are
Streptococcus (warning: I tried to pick links below without terrifying pictures above the fold, but follow them at your own risk)
Pain is what I will attack you with,
Strep infections are painful.
A plague that appears once, what a myth.
Unlike many viral infections, you can get the same bacterial infection again.
In your throat I'll sequester,
Some strains of strep are common in the upper-respiratory tract, and carriers of Group A strep (the kind that causes strep throat) can have "dormant" bacteria in their pharynx.
Now in your hands I'll fester.
Hand washing is one of the most important ways to avoid strep infection, as touching something with strep bacteria on it (like a doorknob) and then touching your face is one of the best (worst?) ways of getting infected.
For if you see me lying around, Unbelievable pain will take you down.
The first part of this line may refer to the persistence of strep on surfaces, and most strep infections are painful; additionally, if you see the bacteria, as in get it in your eyes, and it infects the cornea it can cause a painful eye infection.
Let's, not forget, if I touch you, you can't run away.
Once the bacteria is on you, running won't shake it off (but a good wash with warm water and soap should).
Hints:
You may get hot around me, Your hands and feet will plea.
=
Strep infections are usually accompanied by a fever. One severe complication is rheumatic fever, which causes pain in the wrists and ankles, and in one extreme case of strep infection that made the news last year, a man had to have his feet and hands amputated.
Title: Don't confuse me with the one about chickens!
A common variant of strep infection, especially among children, is scarlet fever, which is commonly classed with chickenpox as a "common childhood rash" and may be mistaken for that disease by parents.
Boils
Pain is what I will attack you with, A plague that appears once, what a myth.
One of the ten biblical plagues to attack Egypt
In your throat I'll sequester, Now in your hands I'll fester.
Two places you can get boils
For if you see me lying around, Unbelievable pain will take you down.
Painful? yes
Let's, not forget, if I touch you, you can't run away.
Because the infection is in your skin
Hint- You may get hot around me, Your hands and feet will plea.
Boiling? Hot?
Don't confuse me with the one about chickens!
Cowpox? A viral skin infection caused by the cowpox or catpox virus.
Pain is what I will attack you with, A plague that appears once, what a myth.
Causes muscle aches and pains. The common misconception is that you can only catch these viruses once.
In your throat I'll sequester, Now in your hands I'll fester.
Starts with a cough and runny nose, and the primary symptom: localized, pustular lesions generally found on the hands and limited to the site of introduction
For if you see me lying around, Unbelievable pain will take you down.
If you see the ulcerous pustules lying around (on your skin), it's going to be painful?
Let's, not forget, if I touch you, you can't run away.
It's an infection spread by physical contact (usually with cows or cats).
What am I?
Hint
You may get hot around me, Your hands and feet will plea.
High fever is another symptom.
Hint 2:
A disease commonly found in children, Sores will most always afflict them.
Kids are more likely to get this than adults.
My guess is also a disease from the bible:
Leprosy
And, while I considered foot-and-mouth disease, too, I felt only leprosy literally has the "if you see me lying around" element (leprosy blankets, clothing carried the disease)
As to the Chicken, I was thinking the riddle, not the pox. You wouldn't want to cross a road to get to the leper colony...
EDIT AFTER HINTS: Well, anyway, before the hints, I liked my answer better than the accepted one, but those hints make it wrong, since if anything, children fared slightly better . . .
The answer is:
The Bubonic Plague (black plague)
A plague that appears once, what a myth.
It occurred multiple times in history over a few centuries if I recall
In your throat I'll sequester
Caused issues withe the throat glands to the point they'd rupture out of the victim's body
Now in your hands I'll fester.
Caused gangrene on the hands.
For if you see me lying around,Unbelievable pain will take you down.
The reference to the rats carrying the virus
Unbelievable pain will take you down.
Fever, swollen glands etc
Let's, not forget, if I touch you, you can't run away.
People were bedridden
