If we take this pattern as a part of a bigger and complete pattern with a well defined rule, then this makes sense:
It is a complete palindrome-like pattern with "mirrored" operations (add-change-add- change-change-remove-change-remove). It eliminates the obscurity how to add white spheres after item 5. It involves operations that have already been used, so ...
The pattern appears to build up, adding dots and colors, leaving the sequence "full" at the fifth square, with no room to add anything after that, so you could make an arbitrary choice as to what happens next, such as:
First, let's divide the $5$ cells like this:
If you observe the colored cells (the non-black cells) upside-down:
The next thing is that, the $5$ cells are actually representing the binary. With black cell denoting $0$ and colored cells denoting $1$. (This refers to hint 2b.) But, it's not a regular binary. It's:
So, if we evaluate the numbers:
Yep, you ...
Partial Answer: I'm not getting far with this. But i think it could be:
This is probably nonesense but I think I can see:
Below are my "workings". I fear I am also barking up the wrong tree, especially since I cant see any further patterns...
So basically my answer was almost a complete guess :)