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My prefix is filthy.

My infix is the prefix.

My suffix is a preposition.

Together, I am to kill someone.

What am I?

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I think you might be

Assassin

My prefix is filthy.

Ass = a person's buttocks.

My infix is the prefix.

Ass, again (same as prefix)

My suffix is a preposition.

In

Together, I am to kill someone.

Assassin = one who murders an important person.

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