My prefix is filthy.
My infix is the prefix.
My suffix is a preposition.
Together, I am to kill someone.
What am I?
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Assassin
My prefix is filthy.
Ass = a person's buttocks.
My infix is the prefix.
Ass, again (same as prefix)
My suffix is a preposition.
In
Together, I am to kill someone.
Assassin = one who murders an important person.