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My prefix is a medium;
Or a substance without colour
Whose suffix isn’t male;
It is used to refer the other

My suffix is a totality
Of what remains on one side
It is also a facility
Which I am used to provide

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This may refer to the

Ethernet - the title describing the cable heads for input & output.

My prefix is a medium; Or a substance without colour

Ether is a medium such as an atmosphere. In chemistry it's a colourless liquid.

Whose suffix isn’t male; It is used to refer the other

Her refers to a female.

My suffix is a totality, Of what remains on one side

Net is what remains after deductions, or the catch.

It is also a facility, Which I am used to provide

The Internet is accessed by Ethernet cable on a wired network.

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  • 2
    $\begingroup$ Congrats on 50k rep! $\endgroup$ – Rand al'Thor Feb 26 at 19:08
  • $\begingroup$ Thank you @Rand for this :) $\endgroup$ – Tom Feb 27 at 9:47
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The poem describes a

VACUUM CLEANER

My prefix is a medium;

A physical vacuum (lack of matter) can be a medium for light waves.

Or a substance without colour

A physical vacuum is colorless.

Whose suffix isn't male;

-um is a Latin suffix for some neuter nouns in the nominative case.

It is used to refer the other

The English word "vacuum" is commonly used as short for "vacuum cleaner".

My suffix is a totality
Of what remains on one side

After a vacuum cleaner is used, the target surface is left "cleaner".

It is also a facility
Which I am used to provide

The purpose of a vacuum cleaner is of course to facilitate cleaning.

The question title, "a two-headed snake that would bite and belch", seems to ring a bell as from some work of literature, movie, etc., that might be relevant, but I can't put my finger on it.

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  • $\begingroup$ A worthy attempt, but the word tag indicates that the answer is a single word in this context, and the title does have a significance to the answer. $\endgroup$ – Ébe Isaac Feb 26 at 8:14

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