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Prefix: A place for you to sleep, the twin cancelled his reservation,

Infix: To give some strings a sweep, and add to the jubilation,

Suffix: Your opinion, just a peep, less a common URL cessation

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The answer is:

instrument

Prefix: A place for you to sleep, the twin cancelled his reservation,

inn; one of the 'twin' letters is absent

Infix: To give some strings a sweep, and add to the jubilation,

strum; to sweep across the strings of an instrument, producing a chord

Suffix: Your opinion, just a peep, less a common URL cessation

comment; take away the 'com'

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