My friend sent me his puzzle: it's
S2LQEQnXk4DP+WsyP1aURD+lz4JSteeOPz3tO7Yiu1dv5fFCr31uegHUpVGqyXk7WjX95TDALus8Gj6nnoGHwj0MLE2AfpB2KTQEIxVvGMyun2XLb+PTcqzVAoFQLr48 in binary, and it came with two hints: "PooP" and "3 6 4 2 5 -5 -4 -6 0 -5".
We have been giving each other these puzzles for a time now and they have been words or phrases so far, but this one may be more complicated. Yes I know my friend is immature.
Edit: Check comments for how I got there, but I have gotten it down to "Aid kIe CT" and the numbers.