Replace the question mark with your solution
That was easy!
The figures are n-cubes with half the size of the larger one. The numbers show in which half the little cube is in each coordinate:
2 1 -> high x, low y -> top right 2 2 -> high x, high y -> bottom right 1 2 2 -> low x, high y, high z -> back's bottom left
The next one is the tesseract, which can be divided in 16 half-sided cubes.
The one we want is at the top right, back and far side in the w-dimension:
See? If I measured my time answering this question, it would be like this:
3%......Thinking about the puzzle
97%.....Trying to draw tesseracts with correct face occlusion on PAINT.
I'm surprised no one took a more practical approach in the meantime.