The final 'crossword' should be filled like this:
5 6 3
1 9 7
2 0 4
The steps to fill it are actually quite tricky and require some logical case-bashing and trawling of data sources, like so...
Step 1:
We can pick up on a key rule straight away as a consequence of column 1's definition...
Since there is a solitary digit not present in the puzzle, each cell must be filled with a different digit 0-9, and one of the digits in that range will not be used at all. This means that none of our 3-digit answers can have a repeated digit.
This can be used to narrow down the candidates for A...
The cubes of the single digits are as follows (with reasons for exclusion if immediately obvious):
0 cubed = 000 NOPE (repeated 0)
1 cubed = 001 NOPE (repeated 0)
2 cubed = 008 NOPE (repeated 0)
3 cubed = 027 MAYBE
4 cubed = 064 NOPE (answer cannot include the digit that is its cube root, by definition)
5 cubed = 125 NOPE (ditto)
6 cubed = 216 NOPE (ditto)
7 cubed = 343 NOPE (repeated 0)
8 cubed = 512 MAYBE
9 cubed = 729 NOPE (includes digit that is its cube root)
This means we have two possible candidates for A: 027 (and so '3' is unused) or 512 (and so '8' is unused). Note that whichever of these we use, this number will make use of a '2' digit, so none of our other answers can use a '2'. Furthermore, our other answers cannot use 0 or 7 together with 1 or 5, since that would invalidate both established candidates for A. Keep all of these facts in mind (we'll need them)...
Step 2:
Next, consider B alongside a helpful table showing all the prime factorisations of 3-digit numbers. We are only interested in those that have exactly 4 distinct prime factors. By examining the table, the candidates are thus (with exclusions from the simplest applications of the established logical rules):
210 (2*3*5*7) NOPE (uses the 2)
330 (2*3*5*11) NOPE (two digits the same)
390 (2*3*5*13) MAYBE
462 (2*3*7*11) NOPE (uses the 2)
510 (2*3*5*17) NOPE (uses both 1 and 0)
546 (2*3*7*13) MAYBE
570 (2*3*5*19) NOPE (uses 0/7 and 5)
690 (2*3*5*23) MAYBE
714 (2*3*7*17) NOPE (uses 7 and 1)
770 (2*5*7*11) NOPE (two digits the same)
798 (2*3*7*19) MAYBE
858 (2*3*11*13) NOPE (two digits the same)
870 (2*3*5*29) MAYBE
910 (2*5*7*13) NOPE (uses both 1 and 0)
930 (2*3*5*31) MAYBE
966 (2*3*7*23) NOPE (two digits the same)
So we've narrowed it down to the following (with more complex exclusions to follow):
390 (2*3*5*13) – would force A=512 with no 8
546 (2*3*7*13) – would force A=027 with no 3
690 (2*3*5*23) – would force A=512 with no 8
798 (2*3*7*19) – would force A=512 with no 8 - CONTRADICTION, so NOPE
870 (2*3*5*29) – would force A=512 with no 8 - CONTRADICTION, so NOPE
930 (2*3*5*31) – would force A=512 with no 8
This leaves us with just 4 candidates - let's see what digits remain in these instances once we take out those we have used:
390 (2*3*5*13) – would force A=512 with no 8 i.e. ---4-67.--
546 (2*3*7*13) – would force A=027 with no 3 i.e. 1-.----89-
690 (2*3*5*23) – would force A=512 with no 8 i.e. --34--7.--
930 (2*3*5*31) – would force A=512 with no 8 i.e. ---4-67.--
This means the last column must contain the digits 189, 347, or 467 in some order.
Step 3:
To solve for C, let's consult a list of the main physical constants. Scanning the first 3 digits of all the entries in this list only produces one viable possibility...
The first radiation constant = 3.74 *10^-16
This fixes our answer for C and thus the others...
i.e. C must be 3.74, B must be 690 and A must be 512.
Or, to present the result as a grid:
5 6 3
1 9 7
2 0 4