Alternative title: Cryptic Division 1: Never Give Up
This is a word division puzzle which uses cryptic clues. If you're unfamiliar with either or both of those, you can click the associated link.
In order to solve the alphametic, you'll first need to fill in the dividend, divisor, and quotient by solving the cryptic clues. I've left the enumerations off to provide a bit of extra challenge. Once you fill those in, the puzzle should be solvable with only arithmetic and logic. The solution is a 10-letter word or phrase found by ordering the letters from 0 through 9. A complete answer should provide this solution along with explanations of the cryptic clues and your path through the alphametic.
As always, I've created an interactive version that will autofill from the grid to the clues and vice versa. Have fun!
Clues:
Response initiated primarily within Stack Exchange, ultimately to get rid of bits of AI content
Dismiss and ignore longtime leadership in chat platform
Broke regular pattern after putting information first, leading to anger

Accessible version:
???
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????|??????
SACK
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ILEKE
ITCTY
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ISTY