Take the numbers 1,3,4,6,9,10. We can make other numbers using these numbers and the operations +,-,*,/. E.g. we can make 244 with:
10 * 3 = 30
30 - 6 = 24
9 + 1 = 10
24 * 10 = 240
240 + 4 = 244
In this case there is more than one way to do it. For example,
3 + 1 = 4
10 * 6 * 4 = 240
240 + 4 = 244
This second solution also doesn't use all the given numbers.
There is only one way to make 713, that is:
9 * 6 = 54
54 - 3 = 51
10 + 4 = 14
51 * 14 = 714
714 - 1 = 713
What is the smallest positive integer that can be made in exactly one way and also requires using each one of 1,3,4,6,9,10? You can use each number exactly once.
As an example, 10 is no good as a target number as you can make it just using the number 10.