From the starting 2, 3, 5, the only prime we can make is 7 (5+2). So 2 and 5 must surround 7 in the configuration after placing 7, with 3 not touching 7.
After this, to get a prime larger than 7, we must include 7. Any combinations with only 2 and 5 are not primes (9, 12, 14), so 3 must be involved. And it's only possible with 2+3+5+7 = 17. So 17 must be surrounded by the other 4 numbers.
So now we have something like this (and any rotations thereof):
A B
X 7 X 7 X Y
X 17 X or X 17 Y
Y Y Y Y Y Y
Where X is a possible location for 2 and 5, and Y is a possible location for 3. Let's call the left configuration as A, the right one B.
The next few primes larger than 17 but less than the sum of all numbers so far (34) are: 19, 23, 29, 31.
Case 1: 19
It's only possible with 2+17. In configuration A, this means it must be one of the corner Y's below, with 2 directly above it, 3 on the next corner, and 5 at either of the other X's. WLOG, 19 at the bottom left. So we have:
X 7 X
2 17 X
19 . 3
To form the next prime, since it must be odd, it must touch odd number of previous numbers except 2. 19+2=21 is not a prime, so we can't expand left. If we involve 19, we can only put 41 at the bottom center. 19+41+3=63 is not a prime, so we can't expand downward, and must expand rightward. By placing 5 at top right, we get 5+7+17+41+3=73, a prime. Unfortunately 73+5+3=81 is not prime. So we stop here, with highest number 73:
. 7 5
2 17 73
19 41 3
If we don't include 19, then the only prime is 7+17+5=29 on the top right. Then the next primes are forced, to arrive at:
107
7 29 71
2 17 5 37
19 3
And since 107+7+29=143=13x11 and 107+29+71=207=3x69, we are done here.
In configuration B, WLOG 2 on the center left. Similar to previously, to get an odd number, the next one should touch 1 or 3 odd numbers (impossible to touch 5 at this point). For 1 odd number, we get the failed 19+2, and for 3 odd numbers, we get it must be 2+17+19+3 as previous (can't touch 5 without also touching 3, and 17 will always be touched).
7 5 .
2 17 Y
19 41 Y
They only way to touch odd numbers of numbers would be to have it touch 3 numbers 41+17+3=61 at the bottom right. Then 19+41+61=121 is not prime and we are done. The highest here is 61.
Case 2: 23
It's not possible to get 23 from any sum of 2, 3, 5, 7, 17.
Case 3: 29
It must be 2+7+17+3=29 or 5+7+17=29. In configuration A, in the first sum since it must touch 7 and 3, it must be on the middle row. WLOG, it's on the left column. On the second sum, we have some freedom. Then we have:
C D E
2 7 X 5 7 X 29 7 X
29 17 X or 29 17 X or 5 17 X
Y Y . . . 3 Y Y Y
In configuration C, again, to touch 3 odd numbers would be either not including 29 (same as Case 1, no prime, or 29, which already exists) or including 29. With including 29, we have 29+17+3=49, not a prime, or 2+29=31 on the left. Then 31+2=33 is not prime, and the next possible touching 3 odd numbers would be 31+2+29+3=65 not a prime. So maximum here is 31.
In configuration D, there is no more place to put a larger prime (29+17+3=49 29+17+3+2=51 both not prime).
Configuration E is already covered in Case 1, since 3 must be involved next (otherwise there won't be enough odd numbers).
In configuration B, it's not possible to touch 7.
Case 4: 31
The only way to form 31 is 2+5+7+17. Not possible in any configuration.
Final result
So maximum prime number we can place is 107 in case 1, like so:
107
7 29 71
2 17 5 37
19 3