Here's a partial answer to get the ball rolling... This puzzle revolves around:
Pokémon ('one of the most popular series of all time', as per the first hint block). We can see this by interpreting the images as follows:
- The first image is a reference to Violet City, an in-game location first visited during the Gen II games Gold/Silver/Crystal.
- The second indicates the first four fifths (note the shading differential) of the letter 'alpha' - i.e. ALPH - and a five letter word beginning with 'R'. This would be RUINS, as the Ruins of Alph is a landmark in the game situated just south of Violet City.
- The final image is a rebus representing the word UNOWN, since the number 1 is 'UN' in French, and the asterisk indicates (in cryptic clue wordplay terms) an anagram of what precedes it, which is the symbol for the South Korean currency, the WON. i.e. We have UN + (anagram of WON), yielding UNOWN.
This is where the title confirms we are on the right track...
Because 'It is said that the two are sometimes related' is part of the Pokédex entry in Pokémon Gold for the Pokémon named Unown which live only in the Ruins of Alph, south of Violet City, which reads in full:
Their shapes look like hieroglyphs on ancient tablets. It is said that the two are somehow related.
This specifically relates to the fact that there are 28 different versions of this particular Pokémon in the game - a unique characteristic of Unown among all other Pokémon - each of which resembles a different letter of the alphabet or punctuation mark. As such it would be possible to spell something out using a selection of them, possibly suggesting that we should be able to spell something out using the binary numbers...

And this is where Part #1 ends and Part #2 begins - interpreting the binary - for which I had one quite good idea that has so far yielded nothing...
I considered that the 'friends' mentioned here might be five 4-letter Pokémon from the game, spelled out alphametic-style, where a different binary number corresponds to a different letter of the alphabet. Translated into decimal, our binary numbers here become:
10 – 9 – 5 – 7
8 – 12 – 12 – 13
11 – 5 – 7 – 6
3 – 15 – 10 – 3
4 – 3 – 11 – 9
Following through with this theory:
The second row of numbers could potentially hide SEEL (the only 4-letter Pokémon with 2 middle letters the same) and the fourth ABRA (the only 4-letter Pokémon with the same starting and ending letters). However, this would render the name of the first of the form Rxxx - and no 4-letter Pokémon begins with 'R'...
So I'm currently still standing at the drawing board as far as interpreting the binary goes, but hopefully the knowledge I've been able to contribute to the first part might enable someone else to take the second part forward...