Certainly I can find $z$ easily:
by calculating the number of powers of $2$ and of $5$ present in the factorisation of $42!$.
This can be done easily using Legendre's formula: the number of powers of a prime $p$ in $N!$ is exactly $\sum_{k=1}^{\infty}\lfloor\frac{N}{p^k}\rfloor$ (this is a finite sum since the summands are all zero for large enough $k$). With $N=42$ and $p=2$, this number is $21+10+5+2+1=39$; with $N=42$ and $p=5$, it is $8+1=9$.
So $42!$ is a multiple of $10^9$, which means $z=0$.
To find $x$ and $y$, it's simply a matter of
solving two simultaneous equations, by considering the fact that $42!$ is a multiple of both $9$ and $11$ and what this implies in terms of digit sums and alternating sums.
Since it's a multiple of $9$, the digit sum ($1+4+0+5+0+0+6+1+1+\cdots$) must be $0$ modulo $9$, which means $x+y+2$ must be $0$ mod $9$, so $x+y$ must be either $7$ or $16$ (it can't be higher since they're single digits).
Since it's a multiple of $11$, the alternating digit sum ($1-4+0-5+0-0+6-1+1+\cdots$) must be $0$ modulo $11$, which means $-x+y-1\equiv0$ modulo $11$, so $x=y-1$.
Therefore, the final answer is $x=3$ and $y=4$.