7
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My prefix is for sure a lie.
My suffix is for sure alive.
My infix is smoking dead.
My whole is in your head.

Note: the "in your head" here is not referring to anyone; it means if one has it at all, it would be in their head.

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2
  • $\begingroup$ I don't have a (w)hole in my head ... $\endgroup$ Jul 9 at 19:49
  • 4
    $\begingroup$ On the contrary, you have several. $\endgroup$
    – Gareth McCaughan
    Jul 9 at 22:13
12
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I think it could be

Shame

Reasons:

My prefix is for sure a lie.

A sham (shame) is an instance of a lie, except of course when you are talking about pillow covers.

My suffix is for sure alive.

I (shame) would have to be alive to be typing this answer.

My infix is smoking dead.

Ham (shame) is smoked and obviously dead.

My whole is in your head.

Shame exists in a person's mind.

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