This is an interesting one.
I will do the same thing that I usually do.
After one week, a hint. After 2 weeks, a hint. After 3 weeks, an answer.
I may change this system.
What number goes in the question mark, and why does it go there?
There is a inputting function that each number is put into... when you undo that function, you get a simple sequence.
If you take this inputting function onto 24862486 you get 4. I will take the next three requests of inputting from the comments.
This has to do with prime factors.
It requires the repeated use of a single function.
This function is related to the Greatest Prime Factor