3
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  • My prefix will despite a fact
  • My suffix tells what to do instead
  • My infix will negatively react
  • My whole is an idea in your head
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7
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I think the answer is

Thought

My prefix will despite a fact

Though = "despite the fact that"

My suffix tells what to do instead

Ought = "used to indicate duty or correctness"

My infix will negatively react

Ugh = "exclamation used to express disgust or horror"

My whole is an idea in your head

Thought = "an idea or opinion produced by thinking, or occurring suddenly in the mind"

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  • $\begingroup$ Ahh, now the wording makes sense. Great job as always :) $\endgroup$ – Sciborg Sep 18 at 15:28

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