My prefix, thus used, is tiny
My suffix, perused, is tiny
My infix, confused, is tiny
My whole is revolting if briny
I wonder - given recent jokes within The Sphinx's Lair (the main PSE chatroom) - whether the answer is:
PICKLE
My prefix, thus used, is tiny
PI is tiny in the sense that it is a single Greek character (or 'only' 3.141... when considered as the mathematical constant).
My suffix, perused, is tiny
ICKLE is a synonym of 'tiny', often used in baby language or particular regional dialects (e.g. West Midlands, in the UK).
My infix, confused, is tiny
LICK is an anagram (note the cryptic clue indicator 'confused') of ICKL, and can be used to mean 'a small application of something' (e.g. 'a lick of paint').
My whole is revolting if briny
Recent chats in The Sphinx's Lair have often (who knows why...) descended into discussions about whether or not pickles (the food) are disgusting or not. It appears that the OP falls firmly into the disgusted camp, considering them 'revolting' in this riddle! (NB 'Briny' can be used as a synonym for 'pickled'...)
My whole is revolting if briny
a salty secretion may sometimes be revolting
My prefix, thus used, is tiny
sec - a second or very short period of time
My suffix, perused, is tiny
ion - atomic sized and tiny to view
My infix, confused, is tiny
trice - a brief moment of time, is the infix anagrammed
Thus used, my prefix is tiny
sic, a small word for "thus used" [though not an abbreviation]
Perused, my suffix is tiny
bag: People fold up newspapers small to make paper bags.
Confused, my infix is tiny
KBA, an abbreviation for "knowledge-based authentication": KBA uses confusion as a barrier.
My whole is revolting if briny
sick bag: It's revolting if it's been used and is thus briny.
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$\begingroup$ That's impressive, but not the answer I had in mind $\endgroup$ – Mohirl Sep 11 '20 at 10:25